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Unexpectedly, some patients who also suffered from psoriasis experienced dramatic reductions in lesion counts. Views Read Edit View history. S4 Prescription only CA: In mouse studies, topical calcipotriol administration to the ear and dorsal skin led to a dose-dependent increase in the production of the epithelial cell-derived cytokine TSLP by keratinocytesand triggered atopic dermatitis at high concentrations.
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The precise mechanism of calcipotriol in remitting psoriasis is not well understood. The efficacy of calcipotriol in the treatment of psoriasis was first noticed by the observation of patients receiving various forms of vitamin D in an osteoporosis study.
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